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KMID : 1159320120140040403
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Korean Journal of Vision Science
2012 Volume.14 No. 4 p.403 ~ p.412
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Influence of Artificial Tear Containing Chlorhexidine Gluconic Acid on Physical Properties of hydrogel contact lens
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Cho Seon-Ahr
Sung A-Young
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Abstract
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Purpose: Artificial tear is considered as an important functional material for wetting condition of human eyes. Chlorhexidine gluconic acid is one of the general materials used for artificial tear. In this study, the impacts of artificial tear including chlorhexidine gluconic acid on the hydrogel contact lens were analyzed in various conditions. Methods: HEMA (2-hydroxyethyl methacrylate) and the cross-linking agent EGDMA (ethylene glycol dimethacrylate) were determined to be used as the basic to produce soft hydrogel contact lens. Also, 20% each of NVP (n-vinyl-2-pyrrolidone) and MMA (methyl methacrylate) were added to this combination for classification of water content. The cast mould method for the thermal copolymerization was used to fabricate the contact lens. The mixture was heated at 80℃for 1 hr 30 mins and 100℃ for 40 mins to produce the contact lens. The copolymerized contact lenses were stored in a 0.9% NaCl normal saline for 24 hours and then in artificial tear for 3, 5, 10 min. and 1, 2, 72hours. respectively. Result: Measurement of the physical properties of the copolymerized polymer showed that water content, refractive index, visible ray transmittance and contact angle were in the range of 26.38~ 49.19%, 1.422~1.455, 90.0~91.4% and 42.00~70.09°, respectively. In addition, in the physical property measured after soaking into artificial tear, the water content, refractive index, visible ray transmittance and contact angle were in the range of 26.39~49.19%, 1.420~1.455, 91.4~87.0%, and 29.55~70.09°, respectively. The changes of the physical property depending on hydration time showed the decrease of refractive index, increase of water content and decrease of contact angle. Conclusion: Artificial tear including chlorhexidine gluconic acid which is used as wetting material, influenced water content, refractive index, contact angle and spectral transmittance of a hydrogel contact lenses.
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KEYWORD
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Chlorhexidine gluconic acid, refractive index, water content, contact angle
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